MacKie @ Budapest

Here the slides of my talk:



Vladana Vukojevic. Interested in the neurology of alcoholics, trying to understand the physiological insurgence of dependence. Quenching of chemical oscillations. Work originated from the work of Graae Sorensen in Copenhagen [Quenching of chemical oscillations , JPC 1987]. The Briggs-Rauscher reaction oscillates (there are youtube videos on this). A stirred reactor with input and output of reactions; oscillations depend on the velocity of feeding, and you can have a supercritical Hopf bifurcation. A quench is a deliberate perturbation of the system, whereby you drive the system from the limit cycle towards the stable manifold. They studied all species that are intermediates in the reaction. There are several models of the BR reaction, so apparently it is not clear how many intermediates there are.  Mentions some stoichiometric stability analysis. They consider a mathematical model for HPA based on cortesol levels, where ethanol is one of the molecules, so by drinking a glass of wine one alters the cycle. The conclusions is that the HPA cycle is affected by ethanol, for example the peak in cortesol is in the evening which affects the sleeping patterns.




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